Premium
Fengphos, a Ferrocene‐Based Chiral Diphosphine: Synthesis and Applications
Author(s) -
Feng Xiangdong,
Pugin Benoît,
Gschwend Björn,
Spindler Felix,
Paas Martin,
Blaser HansUlrich
Publication year - 2009
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.200900134
Subject(s) - ferrocene , chirality (physics) , amine gas treating , chemistry , acrylate , catalysis , combinatorial chemistry , ethyl acrylate , organic chemistry , stereochemistry , electrochemistry , physics , copolymer , chiral symmetry , polymer , electrode , quantum mechanics , nambu–jona lasinio model , quark
Fengphos is a type of ferrocenyl diphosphine incorporating axial as well as central chirality, which is synthesized in three steps from Ugi amine (see scheme). Acting as ligands, they are effective in the Rh‐catalyzed hydrogenation of a wide range of substrates, including dimethyl itaconate ( ee values greater than 99 %) and ethyl β‐acetamido acrylate ( ee values up to 95 %).