“Chronic myelogenous leukemia in primary blast crisis” rather than “de novo   BCR ‐ ABL 1 ‐positive acute myeloid leukemia” | Zendy

Pastoret Cedric | Zendy; Houot Roch | Zendy

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“Chronic myelogenous leukemia in primary blast crisis” rather than “de novo BCR ‐ ABL 1 ‐positive acute myeloid leukemia”

Author(s) -

Pastoret Cedric,

Houot Roch

Publication year - 2017

Publication title -

clinical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

ISSN - 2050-0904

DOI - 10.1002/ccr3.937

Subject(s) - basophilia , chronic myelogenous leukemia , medicine , blast crisis , philadelphia chromosome , myeloid leukemia , breakpoint cluster region , leukemia , cancer research , immunology , chromosomal translocation , biology , receptor , genetics , gene

Key Clinical Message Differentiating chronic myelogenous leukemia in primary blast crisis ( CML ‐ BC ) from de novo BCR ‐ ABL 1 ‐positive acute myeloid leukemia ( AML ) is a diagnostic challenge with therapeutic consequences. In our case, a basophilia, the presence of the Philadelphia chromosome in all metaphases and the strict exclusion of molecular hallmarks of AML lead us to retain the diagnosis of CML ‐ BC rather than BCR ‐ ABL 1+ AML .

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