Open AccessHelicobacter pylori overcomes natural immunity in repeated infections
Author(s) -
Stenström Björn,
Windsor Helen M.,
Fulurija Alma,
Benghezal Mohammed,
Kumarasinghe M. Priyanthi,
Kimura Kazufumi,
Tay Chin Yen,
Viiala Charlie H.,
Ee Hooi C.,
Lu Wei,
Schoep Tobias D.,
Webberley K. Mary,
Marshall Barry J.
Publication year - 2016
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.687
Subject(s) - medicine , helicobacter pylori , immunology , immunity , immune system , helicobacter pylori infection , public health , nursing
Key Clinical Message Repeated experimental reinfection of two subjects indicates that Helicobacter pylori infection does not promote an immune response protective against future reinfection. Our results highlight the importance of preventing reinfection after eradication, through public health initiatives, and possibly treatment of family members. They indicate difficulties for vaccine development, especially therapeutic vaccines.