Open AccessPerioperative management of malignant hyperthermia during general anesthesia: A report of two cases
Author(s) -
Chi Xiaowei,
Xu Yi,
Liao Hongbing,
Chen Tao,
Li Qiang,
Fu Qiang
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.6426
Subject(s) - malignant hyperthermia , medicine , perioperative , complication , ryanodine receptor , anesthesia , dantrolene , hyperthermia , receptor , surgery , calcium
Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality. We present two seemingly typical cases of intraoperative MH development, with details on perioperative assessment and rescue. Postoperative genetic test showed mutations in the ryanodine receptor type 1 gene.