Open AccessUnresectable and chemoresistant conjunctival squamous cell carcinoma on xeroderma pigmentosum treated by salvage radiation therapy: A case report and a review of the literature
Author(s) -
Maimouna Mané,
Sofian Benkhaled,
Latifatou Guèye,
Joséphine Frédérique Mendouga Eyenga,
Papa Macoumba Gaye,
Mamadou Moustapha Dieng,
Dirk Van Gestel
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.6360
Subject(s) - xeroderma pigmentosum , medicine , radiation therapy , basal cell , dermatology , conjunctiva , salvage therapy , surgery , pathology , chemotherapy , dna repair , biochemistry , chemistry , gene
Xeroderma pigmentosum (XP) is a rare genetic disease, which vital prognosis is conditioned by the occurrence of cancers essentially of the skin and ocular surfaces, requiring an early and adapted management. Radiation therapy (RT) is a very effective modality in the therapeutic arsenal alongside surgery, but it remains underused as it is wrongly considered to be deleterious for these patients. In this article, we report the case of a 10‐years‐old girl with XP treated with external beam RT for a squamous cell carcinoma (SCC) of the right ocular conjunctiva. The clinical tolerance was excellent and we obtained a good tumoral response. Therefore, the place of RT in these patients could/should be reconsidered, especially since these suspicions have still not been confirmed.