Open AccessMutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
Author(s) -
Kliebhan Johannes,
Besse Andrej,
KampaSchittenhelm Kerstin,
Schittenhelm Marcus,
Driessen Christoph
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.6296
Subject(s) - mantle cell lymphoma , medicine , warburg effect , mantle (geology) , mutant , lymphoma , cancer research , genetics , glycolysis , gene , biology , metabolism , paleontology
The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.