Mutant   TP53   driving the Warburg Effect in Mantle Cell lymphoma | Zendy

Kliebhan Johannes | Zendy; Besse Andrej | Zendy; KampaSchittenhelm Kerstin | Zendy; Schittenhelm Marcus | Zendy; Driessen Christoph | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma

Author(s) -

Kliebhan Johannes,

Besse Andrej,

KampaSchittenhelm Kerstin,

Schittenhelm Marcus,

Driessen Christoph

Publication year - 2022

Publication title -

clinical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

ISSN - 2050-0904

DOI - 10.1002/ccr3.6296

Subject(s) - lactic acidosis , mantle cell lymphoma , medicine , lymphoma , cancer research , mutant , acidosis , warburg effect , mantle (geology) , hypoglycemia , mutation , cell , pathology , glycolysis , metabolism , biochemistry , biology , gene , paleontology , insulin

The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research