Open AccessIncidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
Author(s) -
Moellgaard Maria Hammer,
Lund Ida Charlotte Bay,
Becher Naja,
Skytte AnneBine,
Andreasen Lotte,
Srebniak Malgorzata Ilona,
Vogel Ida
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.6280
Subject(s) - medicine , malignancy , test (biology) , prenatal diagnosis , obstetrics , pregnancy , pathology , fetus , genetics , biology , paleontology
We present a clinical case where a complex abnormal non‐invasive prenatal test (NIPT) result in a research project revealed carcinoma of the breast in the pregnant woman. Furthermore, the NIPT result did not demonstrate the same fetal chromosomal aberration as the chorion villus sample. A literature search for similar cases was performed identifying 43 unique cases, where abnormal NIPT results were related to maternal malignancy. Malignancy is a rare but important cause of complex abnormal non‐invasive prenatal test (NIPT) results and should be considered when fetal karyotype and abnormal NIPT results are discordant. Furthermore, a follow‐up invasive sample is essential for correct fetal diagnosis when abnormal NIPT results are found.