Open AccessSustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
Author(s) -
Tanaka Ryota,
Matsumoto Asami,
Tatsuta Ryosuke,
Ando Tadasuke,
Shin Toshitaka,
Mimata Hiromitsu,
Itoh Hiroki
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.5914
Subject(s) - medicine , enterohepatic circulation , diarrhea , antimicrobial , mycophenolic acid , disease , crohn's disease , gastroenterology , transplantation , bile acid , microbiology and biotechnology , biology
Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved.