Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report | Zendy

Tanaka Ryota | Zendy; Matsumoto Asami | Zendy; Tatsuta Ryosuke | Zendy; Ando Tadasuke | Zendy; Shin Toshitaka | Zendy; Mimata Hiromitsu | Zendy; Itoh Hiroki | Zendy

Open Access

Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report

Author(s) -

Tanaka Ryota,

Matsumoto Asami,

Tatsuta Ryosuke,

Ando Tadasuke,

Shin Toshitaka,

Mimata Hiromitsu,

Itoh Hiroki

Publication year - 2022

Publication title -

clinical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

ISSN - 2050-0904

DOI - 10.1002/ccr3.5914

Subject(s) - medicine , enterohepatic circulation , diarrhea , antimicrobial , mycophenolic acid , disease , crohn's disease , gastroenterology , transplantation , bile acid , microbiology and biotechnology , biology

Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved.

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