Open AccessPure white cell aplasia an exceptional condition in the immunological conundrum of thymomas: Responses to immunosuppression and literature review
Author(s) -
Céspedes López Roberto,
Amutio Díez Elena,
Martín Martitegui Xabier,
Balerdi Malcorra Amaia,
Insunza Oleaga Lucia,
ArzuagaMéndez Javier,
Moreno Gámiz Maite,
Saiz Camín Mónica,
Aberasturi Plata Yoseba,
GarcíaRuíz Juan Carlos
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.5742
Subject(s) - medicine , immunosuppression , pure red cell aplasia , thymoma , aplasia , immunology , refractory (planetary science) , granulocyte , granulocyte colony stimulating factor , pathology , chemotherapy , bone marrow , biology , astrobiology
Thymomas are tumours frequently associated with autoimmune manifestations or immunodeficiencies like Good syndrome. In rare cases, pure white cells aplasia (PWCA) has been described in association with thymomas. PWCA is characterized by agranulocytosis of autoimmune background primary refractory to granulocyte colony‐stimulating factor (G‐CSF). It is necessary the use of immunosuppressor to allow granulocyte recovery. Without treatment, it could be fatal.