Open AccessImprovement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy
Author(s) -
Ahmed Ziyan S.,
Sherin Rinsha P. V.,
Fonseca Tatiana L.,
Hoang Thanh D.,
Shakir Mohamed K. M.
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.5651
Subject(s) - medicine , depression (economics) , dio2 , antidepressant , levothyroxine , psychiatry , pediatrics , thyroid , deiodinase , thyroid hormones , hippocampus , economics , macroeconomics
We report a 54‐year‐old man with treatment‐resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.