Open AccessPotential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
Author(s) -
Nimura Satomi,
Kitahara Kanayuki,
Ueshima Kazuyo,
Mochizuki Yasuhide,
Momo Kenji,
Shinke Toshiro,
Sasaki Tadanori
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.5592
Subject(s) - tolvaptan , medicine , warfarin , heart failure , drug , drug interaction , myocardial infarction , atrial fibrillation , pharmacology , cardiology , intensive care medicine
Tolvaptan is a key drug for patients with heart failure. Here, we present a 92‐year‐old woman, whose PT‐INR/dose increased from 1.74 to 3.30 after warfarin and tolvaptan co‐administration, and resulted in a large cerebral infarction after warfarin dose down. Therefore, the interaction between these two drugs may be clinically significant.