Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma | Zendy

Motomura Yotaro | Zendy; Umezawa Yoshihiro | Zendy; Arimatsu Tomoyuki | Zendy; Okada Keigo | Zendy; Miura Osamu | Zendy; Kumagai Takashi | Zendy

Open Access

Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma

Author(s) -

Motomura Yotaro,

Umezawa Yoshihiro,

Arimatsu Tomoyuki,

Okada Keigo,

Miura Osamu,

Kumagai Takashi

Publication year - 2022

Publication title -

clinical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

ISSN - 2050-0904

DOI - 10.1002/ccr3.5372

Subject(s) - medicine , bortezomib , lymphoplasmacytic lymphoma , chemotherapy , waldenstrom macroglobulinemia , lymphoma , refractory (planetary science) , lenalidomide , oncology , multiple myeloma , physics , astrobiology

We report a case of fever of unknown origin in a patient with MDS associated with IgM‐MGUS. The patient was positive for MYD88 mutation, and chemotherapy for LPL/WM improved the fever. Analysis of MYD88 and the effect of chemotherapy on LPL/WM finally revealed the latent LPL/WM in this case.

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