Open AccessTherapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
Author(s) -
Reisi Nahid,
Esmaeil Nafiseh,
Gharagozloo Marjan,
Moayedi Behjat
Publication year - 2022
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.5293
Subject(s) - silybum marianum , medicine , intermedia , chelation therapy , deferasirox , chelation , thalassemia , milk thistle , ferritin , traditional medicine , beta thalassemia , pharmacology , serum ferritin , gastroenterology , chemistry , art , organic chemistry , performance art , art history
Abstract Abnormal iron accumulation in vital organs is one of the major complications of β‐thalassemia intermedia (β‐TI). Silymarin, a flavonolignan isolated from Silybum marianum , significantly decreases the serum ferritin levels of β‐TI patients. This finding suggests silymarin as a safe and effective natural iron‐chelating agent for the treatment of iron‐overloaded conditions.