Open AccessNivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
Author(s) -
Arai Kazumori,
Matsuda Masanori,
Nakayasu Hiromasa,
Meguro Shiori,
Kurokami Takafumi,
Kubota Aki,
Iwasaki Tomohiro,
Suzuki Makoto,
Kawaguchi Shinya,
Iwashita Toshihide
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.5174
Subject(s) - medicine , nivolumab , autopsy , mesothelioma , refractory (planetary science) , immunotherapy , immunohistochemistry , immune system , gastroenterology , pathology , immunology , astrobiology , physics
This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discussions are needed regarding the customized management of immune‐related toxicities.