Open AccessGlanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm‐related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency
Author(s) -
Schutgens Roger E. G.,
Urbanus Rolf T.
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.4757
Subject(s) - medicine , thrombasthenia , myeloproliferative neoplasm , glanzmann's thrombasthenia , thrombosis , myeloproliferative disorders , venous thrombosis , platelet , myelofibrosis , platelet aggregation , bone marrow
A patient with Glanzmann Thrombasthenia developed recurrent venous thrombosis with a JAK2 positive myeloproliferative neoplasm. This indicates that the platelet aIIbβIII integrin has no role in venous thrombosis. We discuss the other potential mechanisms that are involved. In addition, we describe the successful use of dabigatran in this patient.