Open AccessJuvenile myelomonocytic leukemia in CBL syndrome associated with germline splice‐site mutations: Two case reports and a literature review
Author(s) -
Cardoso Leila,
GalánGómez Víctor,
CorralSánchez María Dolores,
PérezMartínez Antonio,
Riesco Susana,
IsidoroGarcía María,
Escudero Adela
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.4260
Subject(s) - hemophagocytosis , juvenile myelomonocytic leukemia , medicine , hemophagocytic lymphohistiocytosis , germline , germline mutation , leukemia , immunology , cancer research , mutation , genetics , pathology , biology , gene , disease , bone marrow , stem cell , haematopoiesis , pancytopenia
The clinical and laboratory criteria for hemophagocytic lymphohistiocytosis should be taken into account during the juvenile myelomonocytic leukemia diagnosis, specifically in CBL syndrome, to reveal the presence of primary rather than secondary associated hemophagocytosis.