Open AccessArsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
Author(s) -
Ott Ashley,
Venkataraman Vinayak,
Badran Yousef R.,
Goldman Rose,
Spasic Smiljana,
Vyas Darshali A.,
Amrein Philip,
McAfee Steven,
Brunner Andrew,
Fathi Amir T.,
Narayan Rupa
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.4115
Subject(s) - medicine , arsenic trioxide , acute promyelocytic leukemia , toxicity , diarrhea , acute pancreatitis , intensive care medicine , gastroenterology , arsenic , retinoic acid , biochemistry , chemistry , gene , materials science , metallurgy
Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications.