Open AccessFatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
Author(s) -
Bodi Istvan,
Hagen Ellen Merete,
Ingle Gordon Thorpe,
Lunn Michael P
Publication year - 2020
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3042
Subject(s) - medicine , pure autonomic failure , autopsy , pathology , parkinson's disease , medulla oblongata , disease , orthostatic vital signs , central nervous system , blood pressure
A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.