Open AccessVenetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
Author(s) -
Zappone Elisabetta,
Cencini Emanuele,
Defina Marzia,
Sicuranza Anna,
Gozzetti Alessandro,
Ciofini Sara,
Raspadori Donatella,
Mecacci Bianca,
Bocchia Monica
Publication year - 2020
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3041
Subject(s) - decitabine , venetoclax , medicine , lymphoblastic leukemia , oncology , leukemia , azacitidine , cancer research , chronic lymphocytic leukemia , genetics , dna methylation , gene , biology , gene expression
A case of an early‐relapsed high‐risk T‐ALL with high BCL‐2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2‐positive ALL.