Open AccessReversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
Author(s) -
Lewin Matthew R.,
Bickler Philip,
Heier Tom,
Feiner John,
Montauk Lance,
Mensh Brett
Publication year - 2013
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3
Subject(s) - medicine , envenomation , neostigmine , paralysis , anesthesia , respiratory failure , intensive care medicine , surgery , venom , ecology , biology
Key Clinical Message Neurotoxic snake envenomation can result in respiratory failure and death. Early treatment is considered important to survival. Inexpensive, heat‐stable, needle‐free, antiparalytics could facilitate early treatment of snakebite and save lives, but none have been developed. An experiment using aerosolized neostigmine to reverse paralysis suggests how early interventions could be developed.