Open AccessDental manifestations of hypophosphatasia in children and the effects of enzyme replacement therapy on dental status: A series of clinical cases
Author(s) -
Kiselnikova Larisa,
Vislobokova Elena,
Voinova Victoria
Publication year - 2020
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2769
Subject(s) - hypophosphatasia , medicine , enzyme replacement therapy , dentistry , alkaline phosphatase , dental alveolus , pediatrics , enzyme , disease , biochemistry , chemistry
The most frequent dental signs of hypophosphatasia in children are premature loss of primary teeth, decrease in height of alveolar bone, and malocclusions. Enzyme replacement therapy with Asfotase alfa might be associated with stabilization of dental status.