Open AccessMeropenem pharmacokinetics during relapsing peritonitis due to ESBL‐producing Enterobacteriaciae in a liver transplant recipient
Author(s) -
Shoji Kensuke,
Saito Jumpei,
Oho Yusuke,
Matsumoto Shotaro,
Aoki Satoshi,
Fukuda Akinari,
Sakamoto Seisuke,
Kasahara Mureo,
Capparelli Edmund,
Miyairi Isao
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2398
Subject(s) - meropenem , medicine , peritonitis , dosing , ascites , liver transplantation , pharmacokinetics , minimum inhibitory concentration , gastroenterology , liver disease , transplantation , surgery , antibiotics , microbiology and biotechnology , antibiotic resistance , biology
We report on an 8‐year‐old girl with Wilson disease who developed three episodes of peritonitis due to extended‐spectrum beta‐lactamase‐producing Escherichia coli after liver transplantation. Massive ascites were thought to account for low meropenem concentrations with standard dosing. Extending the infusion achieved higher troughs, greater time above minimum inhibitory concentration.