Open AccessHeart insufficiency after combination of verapamil and metoprolol: A fatal case report and literature review
Author(s) -
Saedder Eva A.,
Thomsen Asser Hedegård,
Hasselstrøm Jørgen Bo,
Jornil Jakob Ross
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2393
Subject(s) - medicine , verapamil , metoprolol , diltiazem , contractility , cardiology , adverse effect , heart rate , blood pressure , calcium
The combination of verapamil or diltiazem with beta‐blockers should be avoided because of potentially profound adverse effects on AV (atrioventricular) nodal conduction, heart rate, or cardiac contractility. This effect is unpredictable but may be enhanced due to CYP2D6 poor metabolizer status which could be a special vulnerability factor.