Open AccessAssessment by miRNA microarray of an autologous cancer antigen‐pulsed adoptive immune ensemble cell therapy (AC‐ACT) approach; demonstrated induction of anti‐oncogenic and anti‐PD‐L1 miRNAs
Author(s) -
Chinami Masanobu,
Iwabuchi Kaoru,
Muto Yoshiteru,
Uchida Yasuhiko,
Arita Ryu,
Shuraim Rana A.,
Adra Chaker N.
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2343
Subject(s) - medicine , microrna , cancer , colorectal cancer , immune system , antigen , adoptive cell transfer , microarray , cancer research , cell therapy , microarray analysis techniques , immunology , cell , t cell , gene expression , gene , biology , biochemistry , genetics
A 60‐year‐old woman with stage IV rectal cancer received adoptive cell therapy with autologous cancer antigen (AC‐ACT) causing induction of anti‐oncogenic and anti‐PD‐L1 miRNAs as assessed by miRNA microarray. More than 1 year after AC‐ACT, metastases have been arrested, and the patient reports good quality of life.