Open AccessCobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
Author(s) -
King Amber C.,
Diamond Eli L.,
Orozco Jennifer S.,
Morse Hannah R.,
Ouyang Linda L.,
Schöder Heiko,
Rampal Raajit K.
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2297
Subject(s) - medicine , erdheim–chester disease , adverse effect , surgery , disease , histiocytosis
Our rechallenge of cobimetinib in an Erdheim‐Chester Disease (ECD) patient for the rare adverse effect, “dropped head syndrome,” with a previously unexplored cobimetinib regimen was successful. Similar to other experiences with targeted agents in ECD, dosing of cobimetinib may vary to mitigate toxicity without impairing efficacy.