Open AccessLight chain lambda myeloma with fatal AL cardiac amyloidosis in a 21‐year‐old patient: A case report and review
Author(s) -
Camus Vincent,
Dubois Sydney,
Thiébaut PierreAlain,
Lepretre Stéphane,
Lenain Pascal,
Picquenot JeanMichel,
Veresezan ElenaLiana,
François Arnaud,
Penther Dominique,
Bauer Fabrice,
Jaccard Arnaud,
Jardin Fabrice
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2165
Subject(s) - medicine , al amyloidosis , amyloidosis , cardiac amyloidosis , multiple myeloma , immunoglobulin light chain , bortezomib , cardiac function curve , cardiology , heart failure , pathology , immunology , antibody
Multi‐organ AL amyloidosis is a therapeutic challenge because of light chain deposits severely damaging the function of concerned organs. Cardiac involvement, which leads to concentric hypertrophy of both ventricles, is particularly severe and leads to poor prognosis regardless of combination chemotherapy. This case pinpoints the relevance of combining clinical, histological, and echocardiographic information in the management of this complex and life‐threatening disease.