Open AccessA hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
Author(s) -
Waite Matthew M. A.,
Martinelli Anthony W.,
Preston Stephen D.,
Gudgin Emma,
Symington Emily,
Rintoul Robert C.,
Peryt Adam,
Coughlin Patrick,
Hayes Paul,
Gilligan David,
Besser Martin
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2106
Subject(s) - medicine , argatroban , lung cancer , surgery , occult , adenocarcinoma , gangrene , crizotinib , dabigatran , idarucizumab , cancer , warfarin , pathology , platelet , alternative medicine , thrombin , malignant pleural effusion , atrial fibrillation
Key Clinical Message We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event.