Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review | Zendy

Montejo Carmen | Zendy; NavarroOtano Judith | Zendy; MayàCasalprim Gerard | Zendy; Campolo Michela | Zendy; CasanovaMollá Jordi | Zendy

Open Access

Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

Author(s) -

Montejo Carmen,

NavarroOtano Judith,

MayàCasalprim Gerard,

Campolo Michela,

CasanovaMollá Jordi

Publication year - 2019

Publication title -

clinical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

ISSN - 2050-0904

DOI - 10.1002/ccr3.2026

Subject(s) - medicine , neurotoxicity , lumbar , intrathecal , methotrexate , sign (mathematics) , anesthesia , surgery , toxicity , mathematical analysis , mathematics

Key Clinical Message Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research