Open AccessAcute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
Author(s) -
Montejo Carmen,
NavarroOtano Judith,
MayàCasalprim Gerard,
Campolo Michela,
CasanovaMollá Jordi
Publication year - 2019
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.2026
Subject(s) - medicine , neurotoxicity , neuroimaging , electromyography , lumbar , spinal cord , paraplegia , lumbosacral joint , anesthesia , physical medicine and rehabilitation , surgery , toxicity , psychiatry
Key Clinical Message Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity.