Open AccessA case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
Author(s) -
Ansari Mohammad,
Auerbach Michael,
Bahrain Huzefa
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.184
Subject(s) - medicine , lethargy , lymphocytosis , bone marrow , myeloid , bone marrow examination , population , myeloid leukemia , chronic lymphocytic leukemia , pathology , chemotherapy , leukemia , immunology , oncology , environmental health
Key Clinical Message An 83 year‐old Caucasian male presented to the emergency room with confusion and lethargy. A complete blood count revealed lymphocytosis, anemia, and thrombocytopenia. A bone marrow examination revealed chronic lymphocytic leukemia ( CLL ), along with a small population of abnormal immature myeloid cells. Chemotherapy for CLL was started. After one cycle, repeat bone marrow examination revealed normalization of the lymphocyte count and a proliferation of the previously noted myeloid population, consistent with acute myeloid leukemia ( AML ). This report presents the microscopic, immunophenotypic, and cytogenetic evidence to document the development of AML after one cycle of chemotherapy for CLL .