Is this really just “fatigue”? A case series of immune‐related central adrenal insufficiency secondary to immune checkpoint inhibitors | Zendy

Nagasaka Misako | Zendy; Abdallah Nadine | Zendy; Samantray Julie | Zendy; Sukari Ammar | Zendy

Open Access

Is this really just “fatigue”? A case series of immune‐related central adrenal insufficiency secondary to immune checkpoint inhibitors

Author(s) -

Nagasaka Misako,

Abdallah Nadine,

Samantray Julie,

Sukari Ammar

Publication year - 2018

Publication title -

clinical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

ISSN - 2050-0904

DOI - 10.1002/ccr3.1567

Subject(s) - hypophysitis , medicine , immune system , immune checkpoint , immunotherapy , adrenal insufficiency , adverse effect , ctla 4 , immunology , bioinformatics , t cell , hormone , pituitary gland , biology

Key Clinical Message While immunotherapy with programmed cell death protein 1 ( PD 1) checkpoint inhibition has shown promising activity against many tumor types, adverse events are common. Hypophysitis is a rare but serious immune‐related event known to occur with anti‐ PD 1 inhibition. It will become more prevalent as the usage of checkpoint inhibitors increases.

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