Open AccessIs this really just “fatigue”? A case series of immune‐related central adrenal insufficiency secondary to immune checkpoint inhibitors
Author(s) -
Nagasaka Misako,
Abdallah Nadine,
Samantray Julie,
Sukari Ammar
Publication year - 2018
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1567
Subject(s) - hypophysitis , medicine , immune system , immune checkpoint , immunotherapy , adrenal insufficiency , adverse effect , ctla 4 , immunology , bioinformatics , t cell , hormone , pituitary gland , biology
Key Clinical Message While immunotherapy with programmed cell death protein 1 ( PD 1) checkpoint inhibition has shown promising activity against many tumor types, adverse events are common. Hypophysitis is a rare but serious immune‐related event known to occur with anti‐ PD 1 inhibition. It will become more prevalent as the usage of checkpoint inhibitors increases.