Open AccessPrimary growth hormone insensitivity and psychomotor delay
Author(s) -
CastillaCortazar Inma,
De Ita Julieta Rodríguez,
Aguirre Gabriel A.,
RodríguezRivera Joel,
GarcíaMagariño Mariano,
MartínEstal Irene,
FloresCaloca Óscar,
DiazOlachea Carlos
Publication year - 2018
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1349
Subject(s) - medicine , short stature , growth hormone , psychomotor learning , endocrinology , idiopathic short stature , hormone , pediatrics , bioinformatics , biology , psychiatry , cognition
Key Clinical Message We report a case of short stature irresponsive to growth hormone ( GH ) replacement therapy. Low GH response to provocative tests and undetectable IGF ‐1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH / IGF ‐1 axis should be performed in these cases to improve diagnosis and therapy.