Open AccessAcute basophilic leukemia associated with the t(16;21)(p11;q22)/ FUS ‐ ERG fusion gene
Author(s) -
Toda Yusuke,
Nagai Yuya,
Shimomura Daiki,
Kishimori Chiyuki,
Tsuda Katsuyo,
Fukutsuka Katsuhiro,
Hayashida Masahiko,
Ohno Hitoshi
Publication year - 2017
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1219
Subject(s) - basophilic , fusion gene , metachromasia , erg , medicine , microbiology and biotechnology , leukemia , pathology , basophil , gene , cancer research , biology , immunology , genetics , ophthalmology , immunoglobulin e , antibody , retinal , staining
Key Clinical Message We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS ‐ ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil‐associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/ FUS ‐ ERG and basophilic differentiation remains unclear.