Open AccessDeferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
Author(s) -
Braga Caroline C. B.,
Benites Bruno Deltreggia,
Albuquerque Dulcineia M.,
Alvarez Marisa C.,
SevaPereira Tiago,
Duarte Bruno K. L.,
Costa Fernando F.,
Gilli Simone C. O.,
Saad Sara T. O.
Publication year - 2017
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.1040
Subject(s) - medicine , deferasirox , genotype , anemia , hepatic dysfunction , liver failure , thalassemia , gastroenterology , pediatrics , gene , genetics , biology
Key Clinical Message This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context.