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Effect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis
Author(s) -
Kir Devika,
Shapero Kayle,
Chatterjee Saurav,
Grimshaw Alyssa,
Oddleifson August,
Spatz Erica S.,
Goldsweig Andrew M.,
Desai Nihar R.
Publication year - 2021
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.29502
Subject(s) - medicine , meta analysis , valve replacement , volume (thermodynamics) , inclusion and exclusion criteria , cardiology , emergency medicine , demography , pathology , physics , alternative medicine , stenosis , quantum mechanics , sociology
Objective We sought to conduct a systematic review and network meta‐analysis to examine the association between institutional transcatheter aortic valve replacement (TAVR) volume and all‐cause mortality. Background Since inception in 2011, there has been an exponential increase in the number of TAVR centers across the world. Multiple studies have questioned if a relationship exists between institutional TAVR volume and patient outcomes. Methods We performed a systematic literature search for relevant articles using a combination of free text terms in the title/abstract related to volume , TAVR , and patient outcomes . Two reviewers independently screened all titles/abstracts for eligibility based on pre‐specified criteria. All‐cause mortality data was pooled from eligible studies and centers were categorized as low‐(30–50 cases), intermediate‐, or high‐volume (75–130 cases) based on their annual TAVR volumes. Results Our search yielded an initial list of 11,153 citations, 120 full text studies were reviewed and 7 studies met all inclusion and exclusion criteria, yielding a total of 1,93,498 TAVRs. Categorized according to center's annual volume; 25,062 TAVRs were performed in low‐, 77,093 in intermediate‐ and 91,343 in high‐volume centers. Network meta‐analysis showed a relative reduction in mortality rates of 37%, 23% and 19%, for high volume versus low volume centers, high volume versus intermediate volume centers and intermediate versus low volume centers, respectively. Conclusions Existing research clearly shows an inverse relationship between annual TAVR procedural volume and all‐cause mortality. We need to focus on development of strong referral networks and consolidation rather than expansion of existing TAVR centers to improve patient outcomes, while ensuring adequate access‐to‐care.