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Management of peri‐device leak following left atrial appendage closure: A systematic review
Author(s) -
Sleiman Jose R.,
Lewis Antonio J.,
Perez Eduardo J.,
Sanchez Alexandra M.,
BaezEscudero Jose L.,
Navia Jose L.,
Asher Craig R.,
Cubeddu Robert J.
Publication year - 2021
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.29495
Subject(s) - medicine , closure (psychology) , leak , percutaneous , discontinuation , surgery , complication , environmental engineering , economics , engineering , market economy
Objective This study aimed to examine the cumulative experience of peri‐device leak (PDL) closure following left atrial appendage (LAA) closure. Background The management of PDL following LAA closure remains controversial. While PDL closure has been proposed, procedural features and clinical outcomes have not been well established. Methods A systematic review of all published cases of PDL closure with available anatomical, procedural, and clinical outcomes was performed. Results We identified 18 indexed publications and 110 cases between April 2013 and March 2020. 71 patients (mean age 72 ± 8 yrs), met study criteria and were included. PDL closure was most common in males, bilobar LAA morphology, and after Watchman procedures. The mean PDL size was 7.6 ± 5.8 mm (range 2–26 mm). Leaks were classified according to size: small (<5 mm; 45%), moderate (≥5–9 mm; 25%), and large (≥10 mm; 30%). Endovascular coils and endovascular plugs were used to close both small and moderate sized leaks, and second LAA closure devices were exclusively used for large PDLs. Successful PDL closure occurred in 90%, and was similar between PDL sizes and types of occluder used. Procedural complication rates were uncommon (2.8%). No strokes were reported following PDL closure at 6 months. Conclusions In patients with PDL for whom discontinuation of OAC may be considered unsafe, percutaneous closure using a tailored approach with either endovascular coils, plugs, or second occluder represents a safe, and feasible alternative associated with favorable clinical outcomes.

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