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Impact of stent designs of second‐generation drug‐eluting stents on long‐term outcomes in coronary bifurcation lesions
Author(s) -
Jang Woo Jin,
Chun Woo Jung,
Park Ik Hyun,
Choi Ki Hong,
Song Young Bin,
Koo BonKwon,
Doh JoonHyung,
Hong SoonJun,
Nam ChangWook,
Gwon HyeonCheol
Publication year - 2021
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.29137
Subject(s) - medicine , percutaneous coronary intervention , stent , everolimus , target lesion , cardiology , myocardial infarction , lesion , drug eluting stent , surgery
Abstract Objectives We compared the long‐term clinical outcomes of four different types of second‐generation drug‐eluting stents (DESs) in coronary bifurcation lesions. Background Clinical outcomes of different designs of second‐generation DESs are not well known in bifurcation lesions. Methods Patients who underwent percutaneous coronary intervention with second‐generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus‐eluting stent (BP‐BES group, n = 514), platinum chromium everolimus‐eluting stent (PtCr‐EES group, n = 473), cobalt nickel zotarolimus‐eluting stent (CoNi‐ZES group, n = 736), or cobalt chromium everolimus‐eluting stent (CoCr‐EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results For 5 years of follow‐up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP‐BES group, 8.2% for PtCr‐EES group, 6.5% for CoNi‐ZES group, and 8.6% for CoCr‐EES group, p = .434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p = .554). In subgroup analysis, the similarity of long‐term outcomes among the four different types of second‐generation DES was consistent across subgroups regardless of side branch treatment ( p for interaction = .691). Conclusion There seems to be no significant difference in long‐term clinical outcomes among patients who received different types of second‐generation DES for coronary bifurcation lesion.