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Effect of a novel transcatheter edge‐to‐edge repair device on the three‐dimensional geometry of mitral valve in degenerative mitral regurgitation
Author(s) -
Ge Zhenyi,
Pan Wenzhi,
Zhou Daxin,
Li Wei,
Wei Lai,
Liu Xianbao,
Pu Zhaoxia,
Shu Xianhong,
Pan Cuizhen,
Ge Junbo
Publication year - 2021
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.29002
Subject(s) - medicine , mitral regurgitation , mitral valve , mitral valve prolapse , reduction (mathematics) , cardiology , regurgitation (circulation) , surgery , geometry , mathematics
Objectives We sought to assess the acute intraprocedural effects of the ValveClamp system in DMR patients on the mitral valve (MV) three‐dimensional (3D) geometry and the association of these effects with mitral regurgitation (MR) reduction. Background Few data are available about the specific impact of transcatheter edge‐to‐edge repair in patients with degenerative mitral regurgitation (DMR). Methods Thirty‐five symptomatic patients (age 74.26 ± 6.61 years) with Grade 3 to 4+ degenerative MR underwent 3D transoesophageal echocardiography (TEE) during ValveClamp implantation. Volumetric data sets were retrospectively analyzed using mitral valve quantitative 3D modeling software. Results Mitral valve annular anterior–posterior (AP) diameter decreased from 33.24 ± 4.03 to 31.12 ± 3.66 mm ( p  < .001), and prolapse height from 4.78 ± 2.19 to 2.32 ± 1.92 mm ( p  < .001), and total exposed leaflet area from 1,110.29 ± 224.21 mm 2 to 1,013.44 ± 228.71 mm ( p = .004). Accordingly, we observed a significant reduction of MR severity after ValveClamp implantation. Multivariable analysis revealed postprocedural MR reduction was associated with shortening in anterior–posterior diameter (coefficient 0.427, p = .008) and reduction in prolapse height (coefficient 0.369, p = .021). Conclusions ValveClamp implantation exerts an acute effect on the 3D MV geometry. Postprocedural reduction in AP diameter and reduction in prolapse height correlates with MR downgrading in patients with degenerative MR.

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