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Usefulness of the updated logistic clinical SYNTAX score after percutaneous coronary intervention in patients with prior coronary artery bypass graft surgery: Insights from the GLOBAL LEADERS trial
Author(s) -
Hara Hironori,
Kogame Norihiro,
Takahashi Kuniaki,
Modolo Rodrigo,
Chichareon Ply,
Tomaniak Mariusz,
Ono Masafumi,
Kawashima Hideyuki,
Gao Chao,
Wang Rutao,
Valkov Veselin D.,
vom Dahl Jürgen,
Steinwender Clemens,
Geisler Tobias,
Lemos Neto Pedro Alves,
Macaya Miguel Carlos,
Garg Scot,
Jüni Peter,
Hamm Christian,
Steg Philippe Gabriel,
Valgimigli Marco,
Vranckx Pascal,
Windecker Stephan,
Farooq Vasim,
Onuma Yoshinobu,
Serruys Patrick W.
Publication year - 2020
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.28898
Subject(s) - medicine , syntax , percutaneous coronary intervention , conventional pci , logistic regression , coronary artery disease , cardiology , framingham risk score , surgery , disease , artificial intelligence , myocardial infarction , computer science
Objectives We aimed to investigate the prognostic utility of the anatomical CABG SYNTAX and logistic clinical SYNTAX scores for mortality after percutaneous coronary intervention (PCI) in patients with prior coronary artery bypass grafts (CABG). Background The anatomical SYNTAX score evaluated the anatomical complexity of coronary artery disease and helped predict the prognosis of patients undergoing PCI. The anatomical CABG SYNTAX score was derived from the anatomical SYNTAX score in patients with prior CABG, whilst the logistic clinical SYNTAX score was developed by incorporating clinical factors into the anatomical SYNTAX score. Methods We calculated the anatomical CABG SYNTAX score and logistic clinical SYNTAX score in 205 patients in the GLOBAL LEADERS trial. The predictive abilities of these scores for 2‐year all‐cause mortality were evaluated. Results Using the median scores as categorical thresholds between low and high score groups, the logistic clinical SYNTAX score was able to discriminate the risk of 2‐year mortality, unlike the anatomical CABG SYNTAX score. The logistic clinical SYNTAX was significantly better at predicting 2‐year mortality, compared to the anatomical CABG SYNTAX score, as evidenced by AUC values in receiver‐operating characteristic curve analysis (0.806 vs. 0.582, p < .001) and integrated discrimination improvement (0.121, p < .001). Conclusions The logistic clinical SYNTAX score was superior to the anatomical CABG SYNTAX score in predicting 2‐year mortality.