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Peripheral artery disease: How do genes and pharmacology interplay?
Author(s) -
Shatila Wassim,
Krajcer Zvonimir
Publication year - 2018
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.27649
Subject(s) - medicine , arterial disease , peripheral , disease , gene , pharmacology , vascular disease , bioinformatics , cardiology , genetics , biology
Key Points In patients with peripheral artery disease, high on‐treatment platelet reactivity (HoTPR) might be associated with worse outcomes for those taking clopidogrel, but not for those taking aspirin. Certain genetic polymorphisms might account for HoTPR. Current literature supports the importance of antiplatelet therapy in treating patients with PAD with clopidogrel, aspirin, or both.