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Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry
Author(s) -
Barbero Umberto,
Scacciatella Paolo,
Iannaccone Mario,
D'Ascenzo Fabrizio,
Niccoli Giampaolo,
Colombo Francesco,
Ugo Fabrizio,
Colangelo Salvatore,
Mancone Massimo,
Calcagno Simone,
Sardella Gennaro,
Amabile Nicolas,
Motreff Pascal,
Toutouzas Konstantinos,
Garbo Roberto,
Tamburino Corrado,
Montefusco Antonio,
Omedè Pierluigi,
Moretti Claudio,
D'amico Maurizio,
Souteyrand Geraud,
Gaita Fiorenzo,
Templin Christian
Publication year - 2018
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.27172
Subject(s) - medicine , culprit , acute coronary syndrome , cardiology , atheroma , thrombus , myocardial infarction
Objectives Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT‐FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. Methods Patients were divided in two groups according to age at presentation: juvenile‐ACS (age ≤ 50 years) and not juvenile‐ACS (age > 50 years). Primary end‐point was the prevalence of plaque rupture (PR). Secondary end point was the prevalence of thin cap fibro atheroma (TCFA), fibrocalcific and fibrotic plaque. Results 285 patients were included, 71 (24.9%) in juvenile‐ACS group and 215 (75.1%) in not juvenile‐ACS group. Younger patients showed a trend for a higher prevalence of TCFA (70 vs. 58%, P = 0.06) and thrombus presence (62 vs. 51%, P = 0.1), while no statistical difference concerning PR (70 vs. 64%, P = 0.29). Of interest patients younger that 35 years showed a higher prevalence of PR compared to patients aged between 35 and 45 or 45 and 50 years (100 vs. 72 vs. 55%, P = 0.03). Culprit plaque in juvenile‐ACS group showed more frequently a reduced mean cap thickness (119 ± 66 vs. 155 ± 95 nm, P = 0.05) and less frequently fibrotic (32 vs. 57%, P < 0.001) or fibrocalcific (17 vs. 36%, P = 0.003) characteristics. Conclusion young patients with ACS show a trend for a higher prevalence of culprit PR, a thinner cap and less fibrotic or fibrocalcific components.