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PFO closure: End of an era or beginning of a new chapter?
Author(s) -
Traina Mahmoud I.,
Tuzcu E. Murat
Publication year - 2017
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.26889
Subject(s) - medicine , patent foramen ovale , closure (psychology) , percutaneous , stroke (engine) , cohort , retrospective cohort study , randomized controlled trial , diabetes mellitus , surgery , pediatrics , cardiology , endocrinology , mechanical engineering , economics , engineering , market economy
Key Points This large long‐term retrospective cohort study shows that percutaneous patent foramen ovale (PFO) closure is safe. Higher rates of recurrent stroke or TIA were noted in older patients (age>55) and those with diabetes and hypertension Randomized trials have failed to show significant benefit from PFO closure for cryptogenic stroke though pooled analyses and longer‐term follow‐up have revealed significant reduction in recurrent strokes. Future studies and longer‐term follow‐up will need to elucidate which subgroups of patients will benefit from closure.