Premium
Adverse outcome of coarctation stenting in patients with Turner syndrome
Author(s) -
van den Hoven Allard T.,
Duijnhouwer Anthonie L.,
Eicken Andreas,
Aboulhosn Jamil,
de Bruin Christiaan,
Backeljauw Philippe F.,
Demulier Laurent,
Chessa Massimo,
Uebing Anselm,
Veldtman Gruschen R.,
Armstrong Aimee K.,
van den Bosch Annemien E.,
Witsenburg Maarten,
RoosHesselink Jolien W.
Publication year - 2017
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.26728
Subject(s) - medicine , coarctation of the aorta , percutaneous , stent , angioplasty , percutaneous coronary intervention , surgery , retrospective cohort study , adverse effect , turner syndrome , aorta , myocardial infarction
Objectives This study examines the outcome and procedural outcomes of percutaneous stent angioplasty for aortic coarctation in patients with Turner syndrome (TS). Background TS occurs in 1 in 2,500 live‐born females and is associated with aortic coarctation. Methods In this multicenter, retrospective cohort study, all patients with TS and a coarctation of the aorta, treated with percutaneous stent implantation were included. The procedural strategies were dictated by local protocols. Adverse events at short‐ and long‐term follow‐up and qualitative parameters concerning the stent implantation were assessed. Results In the largest study to date of TS patients receiving aortic stents, a total of 19 patients from 10 centers were included. Twelve patients were treated for native and 7 for recurrent coarctation. Age at intervention was 16.9 (7–60) years (median; min–max). The coarctation diameter increased significantly from 8.0 mm (2–12) pre‐intervention to 15.0 mm (10–19) post‐intervention ( P < 0.001). Three (15.8%) adverse events occurred within 30 days of the procedure, including two dissections despite the use of covered stents, one resulting in death. At long‐term follow‐up (6.5 years, min–max: 1–16), two additional deaths occurred not known to be stent‐related. Conclusions Though percutaneous treatment of aortic coarctation in TS patients is effective, it is associated with serious morbidity and mortality. These risks suggest that alternative treatment options should be carefully weighed against percutaneous stenting strategies. © 2016 Wiley Periodicals, Inc.