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Brain natriuretic peptide levels variation after left atrial appendage occlusion
Author(s) -
CruzGonzalez Ignacio,
Palazuelos Molinero Jorge,
Valenzuela Maria,
Rada Ignacio,
PerezRivera Jose Angel,
Arribas Jimenez Antonio,
Gabella Tania,
Prieto Ana Beatriz,
Martín Polo Jorge,
Sánchez Pedro L.
Publication year - 2016
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.25985
Subject(s) - medicine , atrial fibrillation , left atrial appendage occlusion , atrial appendage , cardiology , appendage , occlusion , brain natriuretic peptide , stroke (engine) , contraindication , atrial natriuretic peptide , natriuretic peptide , sinus rhythm , heart failure , anatomy , warfarin , pathology , mechanical engineering , alternative medicine , engineering
Objective To explore the variations of brain natriuretic peptide (BNP) secretion after left atrial appendage occlusion. Background Left atrial appendage occlusion has been increasingly performed in the last few years, however little is known about the physiological consequences of left atrial appendage occlusion. Left atrial appendage regulates partially intravascular volume via release of brain natriuretic peptide. Brain natriuretic peptide levels have been related to increased risk of stroke in atrial fibrillation patients. Methods Venous blood samples were obtained in consecutive patients undergoing left atrial appendage occlusion before, 24 hr after device implantation and at the first visit after discharge (45–60 days) for BNP measurement. Results Left atrial appendage occlusion was performed in 34 patients with non‐valvular atrial fibrillation and contraindication to long‐term oral anticoagulation or at high‐risk of bleeding. There were no differences in BNP levels between baseline and 24 hr after device implantation. However left atrial appendage closure resulted in a significant decrease in BNP levels at the first follow‐up visit (45–60 days) compared to baseline measurements (759.90 pg ml −1 vs. 636.90 pg ml −1 , P = 0.013). Conclusions Left atrial appendage occlusion modifies BNP levels. These levels decrease after left atrial appendage occlusion. The clinical consequences of these findings need to be evaluated in further studies. © 2015 Wiley Periodicals, Inc.