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A pathologic study of explanted parachute devices from seven heart failure patients following percutaneous ventricular restoration
Author(s) -
Ladich Elena,
Otsuka Fumiyuki,
Virmani Renu
Publication year - 2013
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.25010
Subject(s) - medicine , thrombus , percutaneous , endocardium , heart failure , autopsy , surgery , ventricle , implant , fibrin , transplantation , thrombosis , cardiology , immunology
Objectives We sought to evaluate the pathologic findings of the percutaneous Parachute device implanted in patients with severe heart failure (HF). Background Currently, most treatments of HF rest on optimal medical therapy with adjunctive interventional or surgical palliative treatments. One such treatment is the Parachute device, which partitions the left ventricle excluding the scarred myocardium from functioning myocardium, and has shown promise in clinical studies. Methods We have examined histopathologically seven cases [six males (age range 43–74 years; mean 56 years) and one female (55 years)] of Parachute device that were either retrieved at autopsy ( n = 4) or during transplantation ( n = 3); implant duration, 15–1,533 days. Results Three patients died of cardiac causes and none died from complications. Histologic early changes (<30 days, n = 1) included adherent thrombus, with focal neutrophil infiltration and degenerating inflammatory cells. Over time (31–300 days, n = 4), there was organized thrombus and development of neoendocardial thickening especially at the free‐edge of the device and its contact with the adjacent endocardium while the base of the device showed varying degrees of fibrin thrombus. The greatest organization of thrombus was observed in devices removed at >300 days (680 and 1533 days); both had fractures of the foot along with strut fracture and one had tearing of the expanded polytetrafluoroethylene. Conclusions The percutaneous Parachute device appears as a promising adjunctive treatment for patients suffering from severe HF. The pathologic changes are those of organizing thrombus with and without inflammation with minor complications of foot and strut fracture. © 2013 Wiley Periodicals, Inc.