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Adjunctive thrombus aspiration versus conventional percutaneous coronary intervention in ST‐elevation myocardial infarction
Author(s) -
Kikkert Wouter J.,
Claessen Bimmer E.,
van Geloven Nan,
Baan Jan,
Vis Marije M.,
Koch Karel T.,
Piek Jan J.,
Tijssen Jan G.P.,
Henriques Jose P.S.
Publication year - 2013
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.24592
Subject(s) - medicine , percutaneous coronary intervention , conventional pci , myocardial infarction , thrombus , cardiology , hazard ratio , propensity score matching , surgery , proportional hazards model , confidence interval
Objectives The objective of this analysis is to determine the effects on mortality of thrombus aspiration during primary percutaneous coronary intervention (PPCI) for ST‐elevation myocardial infarction (STEMI) compared with conventional PCI. Background Adjunctive thrombus aspiration in STEMI improves markers of myocardial reperfusion but evidence for improved survival is limited to the TAPAS trial. Methods We used data of 3,750 consecutive STEMI patients treated with either conventional PCI or thrombus aspiration between August 1, 2001 and January 1, 2009. For each patient, a propensity score was calculated based on clinical and angiographic characteristics, predicting a patient's probability of having been treated with thrombus aspiration. This propensity score was used in several ways to account for differences between patients treated with and without thrombus aspiration. In our primary analysis, patients treated with thrombus aspiration were matched one‐to‐one with patients treated with conventional PCI on their propensity score (1,391 matched pairs). Kaplan Meier and Cox regression models were used to estimate the influence of treatment on one‐year mortality. Results In total, 1,502 patients (40.1%) were treated with thrombus aspiration. In the propensity matched cohort, after one year 7.2% of patients treated with thrombus aspiration had died compared with 9.3% of patients in the control group. The hazard ratio for one‐year mortality in patients treated with thrombus aspiration was 0.76 (95% CI: 0.59–0.99; P = 0.043). The hazard ratio remained materially unaltered and statistically significant in secondary analyses, varying between 0.61 and 0.77. Conclusion The routine use of thrombus aspiration was associated with reduced one‐year mortality in this large real‐world patient cohort. These data support the observed survival benefit in the TAPAS trial. © 2012 Wiley Periodicals, Inc.