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Succinobucol‐eluting stents increase neointimal thickening and peri‐strut inflammation in a porcine coronary model
Author(s) -
Watt Jonathan,
Kennedy Simon,
McCormick Christopher,
Agbani Ejaife O.,
McPhaden Allan,
Mullen Alexander,
Czudaj Peter,
Behnisch Boris,
Wadsworth Roger M.,
Oldroyd Keith G.
Publication year - 2013
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.24473
Subject(s) - medicine , stent , inflammation , restenosis , probucol , thickening , bare metal stent , artery , in vivo , drug eluting stent , coronary arteries , urology , cardiology , chemistry , microbiology and biotechnology , cholesterol , polymer science , biology
Objective The aim of this study was to assess the efficacy of stent‐based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Background : Current drugs and polymers used to coat coronary stents remain suboptimal in terms of long term efficacy and safety. Succinobucol is a novel derivative of probucol with improved antioxidant and anti‐inflammatory properties. Methods Polymer‐free Yukon stents were coated with 1% succinobucol (SucES), 2% rapamycin (RES), or 1% succinobucol plus 2% rapamycin solutions (SucRES) and compared with a bare metal stent (BMS). Results The in vivo release profile of SucES indicated drug release up to 28 days (60% drug released at 7 days); 41 stents (BMS, n = 11; SucES, n =10; RES, n = 10; SucRES, n = 10) were implanted in the coronary arteries of 17 pigs. After 28 days, mean neointimal thickness was 0.31 ± 0.14 mm for BMS, 0.51 ± 0.14 mm for SucES, 0.19 ± 0.11 mm for RES, and 0.36 ± 0.17 mm for SucRES ( P < 0.05 for SucES vs. BMS). SucES increased inflammation and fibrin deposition compared with BMS ( P < 0.05), whereas RES reduced inflammation compared with BMS ( P < 0.05). Conclusion In this model, stent‐based delivery of 1% succinobucol using a polymer‐free stent platform increased neointimal formation and inflammation following coronary stenting. © 2012 Wiley Periodicals, Inc.