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Chronic kidney disease and the risk of stent thrombosis after percutaneous coronary intervention with drug‐eluting stents
Author(s) -
Miao Yu,
YuJie Zhou,
ZhiJian Wang,
DongMei Shi,
YuYang Liu,
YingXin Zhao,
Fei Gao,
ShiWei Yang,
DeAn Jia
Publication year - 2012
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.23464
Subject(s) - medicine , percutaneous coronary intervention , conventional pci , renal function , kidney disease , coronary artery disease , incidence (geometry) , stent , hazard ratio , cardiology , drug eluting stent , surgery , myocardial infarction , confidence interval , physics , optics
Abstract Background Chronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug‐eluting stent (DES) implantation are limited.Objectives This study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function.Methods We consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1‐year definite or probable ST.Results Four hundred and forty‐five participants (15.5%) had CKD before procedure. The incidence of 1‐year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1‐year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165–0.951, P = 0.038).Conclusion CKD is significantly associated with increased incidence of 1‐year definite or probable ST in patients undergoing PCI with DES. © 2012 Wiley Periodicals Inc.