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Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study)
Author(s) -
Liu Peng,
Jiang Jie,
Li Jianping,
Hong Tao,
Zhang Yan,
Yu Ronghui,
Jia Jia,
Huo Yong
Publication year - 2011
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.23171
Subject(s) - medicine , percutaneous coronary intervention , conventional pci , myocardial infarction , cardiology , atorvastatin , coronary artery disease , clinical endpoint , acute coronary syndrome , troponin i , statin , unstable angina , population , randomized controlled trial , environmental health
Background: Myocardial necrosis is related to higher incidence of cardiovascular events and higher mortality rates during follow‐up. Statins have been demonstrated to lower the risk of periprocedural myocardial infarction. The aim of this study is to evaluate the safety and efficacy of intensive statin therapy and the long‐term outcome of patients in the Asian population. Study design: Approximately 1,100 patients with stable angina or non‐ST elevation acute coronary syndrome undergoing selective percutaneous coronary intervention (PCI) are enrolled in this study. Patients are randomized either to the experimental group (80 mg atorvastatin 80 mg/day × 2 days before and 40 mg/day × 30 days after PCI) or to the control group (usual care). Creatine kinase‐MB (CK‐MB), troponin I (cTnI), and serum creatine are measured at 24 hours after the procedure. The total follow‐up period is 6 months. The primary objective is to evaluate the efficacy of intensive atorvastatin treatment compared with usual care in reducing 30‐day primary cardiovascular endpoints in patients undergoing selective PCI. Secondary endpoints are changes in myocardial biomarkers (cTnI, CK‐MB) and hs‐CRP, CIN morbidity, 6‐month clinical outcomes, and safety. Conclusion: The result of the ISCAP study will provide important evidence on the efficacy and safety of periprocedural serial intensive statin treatment in Asian patients with coronary artery disease undergoing selective PCI. © 2011 Wiley Periodicals, Inc.