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Duration of dual antiplatelet therapy and outcomes after coronary stenting with the genous™ bio‐engineered R stent™ in patients from the e‐healing registry
Author(s) -
Damman Peter,
Klomp Margo,
Silber Sigmund,
Beijk Marcel A.,
Ribeiro Expedito E.,
Suryapranata Harry,
Wójcik Jaroslaw,
Sim Kui Hian,
Tijssen Jan G.P.,
de Winter Robbert J.
Publication year - 2011
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.23156
Subject(s) - medicine , hazard ratio , post hoc analysis , cardiology , conventional pci , discontinuation , myocardial infarction , confidence interval , stent , proportional hazards model , coronary stenting , surgery , restenosis
Objective : We investigated the relation between duration of dual antiplatelet therapy (DAPT) and clinical outcomes up to 12 months after Genous™ endothelial progenitor cell capturing R stent™ placement in patients from the e‐HEALING registry. Background : Cessation of (DAPT) has been shown to be associated with the occurrence of stent thrombosis (ST). After Genous placement, 1 month of DAPT is recommended. Methods : Patients were analyzed according to continuation or discontinuation of DAPT at a 30‐day and 6‐month landmark, excluding patients with events before the landmark. Each landmark was a new baseline, and outcomes were followed up to 12 months after stenting. The main outcome for our current analysis was target vessel failure (TVF), defined as target vessel‐related cardiac death or myocardial infarction and target vessel revascularization. Secondary outcomes included ST. (Un)adjusted hazard ratios (HR) for TVF were calculated with Cox regression. Results : No difference was observed in the incidence of TVF [HR: 1.03; 95% confidence intervals (CI): 0.65–1.65, P = 0.89] in patients continuing DAPT ( n = 4,249) at 30 days versus patients stopped ( n = 309), and HR: 0.82 (95% CI: 0.55–1.23, P = 0.34) in patients continuing DAPT ( n = 2,654) at 6 months versus patients stopped [ n = 1,408] DAPT). Furthermore, no differences were observed in ST. Even after addition of identified independent predictors for TVF, adjusted TVF hazards were comparable. Conclusions : In a post‐hoc analysis of e‐HEALING, duration of DAPT was not associated with the occurrence of the outcomes TVF or ST. The Genous stent may be an attractive treatment especially in patients at increased risk for (temporary) cessation of DAPT or bleeding. © 2011 Wiley Periodicals, Inc.