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Adult stem cells in the treatment of acute myocardial infarction
Author(s) -
Sharif Faisal,
Bartunek Jozef,
Vanderheyden Marc
Publication year - 2010
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.22620
Subject(s) - medicine , myocardial infarction , clinical trial , stem cell therapy , stem cell , homing (biology) , intensive care medicine , cell therapy , multidisciplinary approach , cardiology , transplantation , ecology , biology , genetics , social science , sociology
Stem cell therapy has emerged as a novel therapeutic treatment alternative for early and end stage LV dysfunction. The rapid translation into clinical trials has left many questions unanswered. Moreover, results of randomized trials in the setting of acute myocardial infarction are controversial, emphasizing a need for further basic and translational research to improve understanding of cell functionality. This review attempts to summarize some of the functional issues related to cell therapy and also evaluate the current status of stem cell clinical trials. Although results to date have shown modest improvement in left ventricular function, the progress should follow a coordinated, multidisciplinary, and well designed path to address issues of cell homing, cell retention, and also look at outcomes beyond physiological parameters. © 2010 Wiley‐Liss, Inc.